Installing for Single-Player Games:
It is recommended to install using Gale, r2modman or Thunderstore Mod Manager. Dependencies are installed for you.
For locally-managed Dedicated Servers:
It is recommended to use Gale's Profile Sync feature for your clients, and use something like BakaLoader for your server, which can connect to the Gale Profile Sync and help manage the process easily.
Note: Both apps are free, though donations are appreciated!